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You can now try 15ml of Adipeau Face Cream “Free” with Every Adipeau Strong Body Gel Purchase.
Don’t rub it in!
This is the first rule of Adipeau.
Finger paint on instead. Active Face Cream can only get to the skin’s root structure by sliding down the mostly invisible hair follicles of the facial skin. Rubbing the cream in causes the natural actives to get stuck in the outer layer. Finger painting the cream gives it time and access to the hair follicles.
Adipeau Active Face Cream is a skincare product designed to address deep lines, particularly around sensitive areas like the eyes. Do not expect quick results although some users have reported improvements after just a few days, consistent morning and night application over an extended period will provide the optimal outcome. Unlike overnight solutions, Adipeau requires regular and daily use for the best results. Most individuals notice changes around the 4–6-week mark, with more substantial improvements observed after approximately 10 weeks.
Your skin is capable of remarkable things. You need to be patient and dedicated with your facial fitness practice. Nothing happens overnight and nothing remarkable happens in isolation. Diet, exercise, sun care, and the other elements of your skincare regimen should all work together to achieve optimal facial fitness.
Ivan received his scientific training in inflammation research at Sanofi. Before he started Adipeau, he founded two successful companies. One developed a treatment for a rare paediatric genetic disease (Farber). The other identified patient-specific drug combinations for colon cancer.
Ivan is now dedicated to researching how the remarkable regenerative powers of the skin can be harnessed to advance facial and whole-body fitness. He was recently published in a notable peer-reviewed journal, Aesthetic Plastic Surgery.
Dr. Tower received his medical degree from the University of Chicago, Pritzker School of Medicine, prior to completing his Otolaryngology-Head and Neck Surgery residency at Yale School of Medicine. At Yale, he trained under world-renowned head and neck and facial plastic surgeons and developed interests in facial anatomy and facial aging. Dr. Tower has published numerous peer-reviewed articles and book chapters on plastic surgery and has presented his research at national meetings.
Ivan Galinin now specializes in facial plastic and reconstructive surgery on Manhattan’s Upper East Side and is a member of the American Academy of Facial Plastic and Reconstructive Surgery.
These questions may seem simple but many people, including many practitioners, would struggle to answer them correctly.
Yes, dermal white adipose cells are unique to the skin.
Cite
Driskell RR, Jahoda CA, Chuong CM, Watt FM, Horsley V. Defining dermal adipose tissue. Exp Dermatol. 2014 Sep;23(9):629-31. doi: 10.1111/exd.12450. PMID: 24841073; PMCID: PMC4282701.
No, new fat cells are constantly being made to replace ones that die.
Cite
Nguyen HP, Lin F, Yi D, Xie Y, Dinh J, Xue P, Sul HS. Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis. Dev Cell. 2021 May 17;56(10):1437-1451.e3. doi: 10.1016/j.devcel.2021.03.026. Epub 2021 Apr 19. PMID: 33878347; PMCID: PMC8137669.
Yes, dermal adipocytes have unique regenerative powers.
Cite
Chon SH, Pappas A. Differentiation and characterization of human facial subcutaneous adipocytes. Adipocyte. 2014 Nov 14;4(1):13-21. doi: 10.4161/21623945.2014.955402. PMID: 26167398; PMCID: PMC4496965.
In the lower dermis, in and around the vellus hair follicles.
Cite
Nicu C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol. 2018 Jun;27(6):589-602. doi: 10.1111/exd.13549. PMID: 29603400.
There is no separation between dermal and subcutaneous adipocytes.
Cite
Nicu C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol. 2018 Jun;27(6):589-602. doi: 10.1111/exd.13549. PMID: 29603400.
Immature fat cells or pre-adipocytes are more numerous than the mature fat cells.
Cite
Roberta Florido, Tamara Tchkonia, James L. Kirkland, Chapter 5 – Aging and Adipose Tissue, Editor(s): Edward J. Masoro, Steven N. Austad, In Handbooks of Aging, Handbook of the Biology of Aging (Seventh Edition), Academic Press, 2011, Pages 119-139, ISBN 9780123786388
Yes, small molecules less than 500 daltons are readily able to reach the skin’s fat cells via the hair follicle path.
Cite
Abd E, Benson HAE, Roberts MS, Grice JE. Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies. Skin Pharmacol Physiol. 2018;31(5):252-260. doi: 10.1159/000489857. Epub 2018 Jul 12. PMID: 30001555.
Yes, as adipocytes become large they stop promoting adipogenesis and start suppressing adipogenesis.
Cite
Stenkula KG, Erlanson-Albertsson C. Adipose cell size: importance in health and disease. Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R284-R295. doi: 10.1152/ajpregu.00257.2017. Epub 2018 Apr 11. PMID: 29641234.
Yes, large adipocytes instruct fibroblasts to reduce collagen, elastin and hyaluronic acid production by up to 80 percent.
Cite
Ezure T, Amano S. Negative regulation of dermal fibroblasts by enlarged adipocytes through release of free fatty acids. J Invest Dermatol. 2011 Oct;131(10):2004-9. doi: 10.1038/jid.2011.145. Epub 2011 Jun 23. PMID: 21697886.
Yes, KPE reduces cell size by stimulating fat cells to release lipid.
Cite
Okabe Y, Shimada T, Horikawa T, Kinoshita K, Koyama K, Ichinose K, Aburada M, Takahashi K. Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora. Phytomedicine. 2014 May 15;21(6):800-6. doi: 10.1016/j.phymed.2014.01.014. Epub 2014 Mar 11. PMID: 24629599.
Yes, safflower seed oil is made of mostly long chain linoleic and oleic fatty acids.
Cite
Deliorman Orhan D, Pekacar S, Ulutaş OK, Özüpek B, Sümmeoğlu D, Berkkan A. Assessment of Commercially Safflower Oils (Carthami Oleum Raffinatum) in Terms of European Pharmacopoeia Criteria and Their Weight Control Potentials. Turk J Pharm Sci. 2022 Jun 27;19(3):273-279. doi: 10.4274/tjps.galenos.2021.84484. PMID: 35775241; PMCID: PMC9254086.
Yes, long chain fatty acids increase conversion of pre-adipocytes significantly.
Cite
Kokta TA, Strat AL, Papasani MR, Szasz JI, Dodson MV, Hill RA. Regulation of lipid accumulation in 3T3-L1 cells: insulin-independent and combined effects of fatty acids and insulin. Animal. 2008 Jan;2(1):92-9. doi: 10.1017/S1751731107000936. PMID: 22444967.
Yes, topically applied KPE penetrates readily into the dermal white adipose tissue.
Cite
Tuntiyasawasdikul S, Limpongsa E, Jaipakdee N, Sripanidkulchai B. Transdermal permeation of Kaempferia parviflora methoxyflavones from isopropyl myristate-based vehicles. AAPS PharmSciTech. 2014 Aug;15(4):947-55. doi: 10.1208/s12249-014-0122-y. Epub 2014 May 3. PMID: 24789664; PMCID: PMC4113614.
Yes, topically applied long-chain fatty acids penetrate readily into the dermal white adipose tissue.
Cite
Raufast V, Mavon A. Transfollicular delivery of linoleic acid in human scalp skin: permeation study and microautoradiographic analysis. Int J Cosmet Sci. 2006 Apr;28(2):117-23. doi: 10.1111/j.1467-2494.2006.00303.x. PMID: 18492146.