How to Use Adipeau

Don’t rub it in!

This is the first rule of Adipeau.

Finger paint on instead. Active Face Cream can only get to the skin’s root structure by sliding down the mostly invisible hair follicles of the facial skin. Rubbing the cream in causes the natural actives to get stuck in the outer layer. Finger painting the cream gives it time and access to the hair follicles.

How long does it take Adipeau to work?

Adipeau Active Face Cream is a skincare product designed to address deep lines, particularly around sensitive areas like the eyes. Do not expect quick results although some users have reported improvements after just a few days, consistent morning and night application over an extended period will provide the optimal outcome. Unlike overnight solutions, Adipeau requires regular and daily use for the best results. Most individuals notice changes around the 4–6-week mark, with more substantial improvements observed after approximately 10 weeks.

Your skin is capable of remarkable things. You need to be patient and dedicated with your facial fitness practice. Nothing happens overnight and nothing remarkable happens in isolation. Diet, exercise, sun care, and the other elements of your skincare regimen should all work together to achieve optimal facial fitness.

How to Apply Adipeau

Can I use retinol with Adipeau?

For those wondering about compatibility with retinol or Retin-A, it can be confirmed that Adipeau can be used in conjunction with these vitamin-A derivatives. Many customers have successfully incorporated the cream into their skincare routines without issues.

Ingredients

Water (Aqua), Carthamus Tinctorius (Safflower) Seed Oil, Dicaprylyl Carbonate, Glycerin, Bis-Diglyceryl Polyacyladipate-2, Glyceryl Oleate Citrate, Cetearyl Alcohol, Cucumis Sativus (Cucumber) Fruit Extract, Kaempferia Parviflora Rhizome Extract, Oryza Sativa (Rice) Bran Wax, Carbomer, Tocopheryl Acetate, Xanthan Gum, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Helianthus Annuus (Sunflower) Seed Oil, Ethylhexylglycerin, Sodium Hydroxide

Can I use retinol with Adipeau?

For those wondering about compatibility with retinol or Retin-A, it can be confirmed that Adipeau can be used in conjunction with these vitamin-A derivatives. Many customers have successfully incorporated the cream into their skincare routines without issues.

Ingredients

Water (Aqua), Carthamus Tinctorius (Safflower) Seed Oil, Dicaprylyl Carbonate, Glycerin, Bis-Diglyceryl Polyacyladipate-2, Glyceryl Oleate Citrate, Cetearyl Alcohol, Cucumis Sativus (Cucumber) Fruit Extract, Kaempferia Parviflora Rhizome Extract, Oryza Sativa (Rice) Bran Wax, Carbomer, Tocopheryl Acetate, Xanthan Gum, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Helianthus Annuus (Sunflower) Seed Oil, Ethylhexylglycerin, Sodium Hydroxide

The Founder - Ivan Galinin

Ivan received his scientific training in inflammation research at Sanofi. Before he started Adipeau, he founded two successful companies. One developed a treatment for a rare paediatric genetic disease (Farber). The other identified patient-specific drug combinations for colon cancer.

Ivan is now dedicated to researching how the remarkable regenerative powers of the skin can be harnessed to advance facial and whole-body fitness. He was recently published in a notable peer-reviewed journal, Aesthetic Plastic Surgery.

Dr. Tower received his medical degree from the University of Chicago, Pritzker School of Medicine, prior to completing his Otolaryngology-Head and Neck Surgery residency at Yale School of Medicine. At Yale, he trained under world-renowned head and neck and facial plastic surgeons and developed interests in facial anatomy and facial aging. Dr. Tower has published numerous peer-reviewed articles and book chapters on plastic surgery and has presented his research at national meetings.

Ivan Galinin now specializes in facial plastic and reconstructive surgery on Manhattan’s Upper East Side and is a member of the American Academy of Facial Plastic and Reconstructive Surgery.

Important Questions – Peer-reviewed answers.

These questions may seem simple but many people, including many practitioners, would struggle to answer them correctly.

Yes, dermal white adipose cells are unique to the skin.

Cite

Driskell RR, Jahoda CA, Chuong CM, Watt FM, Horsley V. Defining dermal adipose tissue. Exp Dermatol. 2014 Sep;23(9):629-31. doi: 10.1111/exd.12450. PMID: 24841073; PMCID: PMC4282701.

No, new fat cells are constantly being made to replace ones that die.

Cite

Nguyen HP, Lin F, Yi D, Xie Y, Dinh J, Xue P, Sul HS. Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis. Dev Cell. 2021 May 17;56(10):1437-1451.e3. doi: 10.1016/j.devcel.2021.03.026. Epub 2021 Apr 19. PMID: 33878347; PMCID: PMC8137669.

Yes, dermal adipocytes have unique regenerative powers.

Cite

Chon SH, Pappas A. Differentiation and characterization of human facial subcutaneous adipocytes. Adipocyte. 2014 Nov 14;4(1):13-21. doi: 10.4161/21623945.2014.955402. PMID: 26167398; PMCID: PMC4496965.

In the lower dermis, in and around the vellus hair follicles.

Cite

Nicu C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol. 2018 Jun;27(6):589-602. doi: 10.1111/exd.13549. PMID: 29603400.

There is no separation between dermal and subcutaneous adipocytes.

Cite

Nicu C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. A guide to studying human dermal adipocytes in situ. Exp Dermatol. 2018 Jun;27(6):589-602. doi: 10.1111/exd.13549. PMID: 29603400.

Immature fat cells or pre-adipocytes are more numerous than the mature fat cells.

Cite

Roberta Florido, Tamara Tchkonia, James L. Kirkland, Chapter 5 – Aging and Adipose Tissue, Editor(s): Edward J. Masoro, Steven N. Austad, In Handbooks of Aging, Handbook of the Biology of Aging (Seventh Edition), Academic Press, 2011, Pages 119-139, ISBN 9780123786388

Yes, small molecules less than 500 daltons are readily able to reach the skin’s fat cells via the hair follicle path.

Cite

Abd E, Benson HAE, Roberts MS, Grice JE. Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies. Skin Pharmacol Physiol. 2018;31(5):252-260. doi: 10.1159/000489857. Epub 2018 Jul 12. PMID: 30001555.

Yes, as adipocytes become large they stop promoting adipogenesis and start suppressing adipogenesis.

Cite

Stenkula KG, Erlanson-Albertsson C. Adipose cell size: importance in health and disease. Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R284-R295. doi: 10.1152/ajpregu.00257.2017. Epub 2018 Apr 11. PMID: 29641234.

Yes, large adipocytes instruct fibroblasts to reduce collagen, elastin and hyaluronic acid production by up to 80 percent.

Cite

Ezure T, Amano S. Negative regulation of dermal fibroblasts by enlarged adipocytes through release of free fatty acids. J Invest Dermatol. 2011 Oct;131(10):2004-9. doi: 10.1038/jid.2011.145. Epub 2011 Jun 23. PMID: 21697886.

Yes, KPE reduces cell size by stimulating fat cells to release lipid.

Cite

Okabe Y, Shimada T, Horikawa T, Kinoshita K, Koyama K, Ichinose K, Aburada M, Takahashi K. Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora. Phytomedicine. 2014 May 15;21(6):800-6. doi: 10.1016/j.phymed.2014.01.014. Epub 2014 Mar 11. PMID: 24629599.

Yes, safflower seed oil is made of mostly long chain linoleic and oleic fatty acids.

Cite

Deliorman Orhan D, Pekacar S, Ulutaş OK, Özüpek B, Sümmeoğlu D, Berkkan A. Assessment of Commercially Safflower Oils (Carthami Oleum Raffinatum) in Terms of European Pharmacopoeia Criteria and Their Weight Control Potentials. Turk J Pharm Sci. 2022 Jun 27;19(3):273-279. doi: 10.4274/tjps.galenos.2021.84484. PMID: 35775241; PMCID: PMC9254086.

Yes, long chain fatty acids increase conversion of pre-adipocytes significantly.

Cite

Kokta TA, Strat AL, Papasani MR, Szasz JI, Dodson MV, Hill RA. Regulation of lipid accumulation in 3T3-L1 cells: insulin-independent and combined effects of fatty acids and insulin. Animal. 2008 Jan;2(1):92-9. doi: 10.1017/S1751731107000936. PMID: 22444967.

Yes, topically applied KPE penetrates readily into the dermal white adipose tissue.

Cite

Tuntiyasawasdikul S, Limpongsa E, Jaipakdee N, Sripanidkulchai B. Transdermal permeation of Kaempferia parviflora methoxyflavones from isopropyl myristate-based vehicles. AAPS PharmSciTech. 2014 Aug;15(4):947-55. doi: 10.1208/s12249-014-0122-y. Epub 2014 May 3. PMID: 24789664; PMCID: PMC4113614.

Yes, topically applied long-chain fatty acids penetrate readily into the dermal white adipose tissue.

Cite

Raufast V, Mavon A. Transfollicular delivery of linoleic acid in human scalp skin: permeation study and microautoradiographic analysis. Int J Cosmet Sci. 2006 Apr;28(2):117-23. doi: 10.1111/j.1467-2494.2006.00303.x. PMID: 18492146.

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